Custom Peptides
Cayman Chemical BrequInarsodIum salt 10mg
A DHODH inhibitor (IC50 = ~20 nM); selective for DHODH over a panel of greater than 400 kinases at 100 nM; induces differentiation of ER-HoxA9, U937, and THP-1 cells in vitro (EC50s = ~1 µM); induces differentiation of tumor cells and reduces tumor growth in a THP-1 mouse xenograft model at 15 mg/kg three times daily or 5 mg/kg per day; induces differentiation of bone marrow leukemic cells and increases survival In a retroviral transduction mouse model of HoxA9 + Meis1 AML
Cayman Chemical AmphoTRIcIn B methyl esTR 10mg
A polyene antiviral and antifungal agent; impairs viral particle production, as well as viral entry and infectivity, in HIV-1-infected TZM-bl cells at 10 µM; inhibits replication of HIV-1 clinical isolates from a variety of clades (IC50s = 0.5-5.5 µM); active against S. cerevisiae (MIC = 0.25 UG/ml); reduces mortality in a mouse model of C. albicans infection at 1 and 10 mg/kg
Cayman Chemical MethylprotodIoscIn 10mg
A steroidal saponin with diverse biological activities; suppresses EGF- or PMA-induced MUC5AC mucin production in H292 cells at 1 µM; inhibits the proliferation of HeLa cervical cancer cells (IC50 = 18.31 µM); induces production of ROS, apoptosis, and cell cycle arrest at the G2/M phase in HeLa cells; decreases bone loss and prevents decreases in bone mineral content and bone mineral density in a mouse model of ovariectomy-induced osteoporosis at 50 mg/kg
Cayman Chemical CoblopasvIr 10mg
A pan-genotypic inhibitor of HCV NS5A; inhibits viral replication of the HCV genotypes 1a, -1b, -3a, -4a, -5a, and -6a in cellular assays and genotype 2a in a cell-free assay
Cayman Chemical t232trIfluoroacetAT salt 10mg
A synthetic peptide derivative of somatostatin; binds to somatostatin receptors in isolated rat synaptosomal membranes (IC50 = ~0.1 nM); inhibits the proliferation of P388 murine and HL-60 human leukemia cells at 30 and 60 UG/ml; reduces tumor volume in an HL-60 mouse xenograft model from 3-12 UG/animal per day; inhibits capsaicin-induced intradermal neutrophil accumulation and EAr edema in rats; inhibits mechano-nociceptive hyperalgesia in rats from 5-20 UG/kg, i.p.
Cayman Chemical SetmelnotIdetrIfluoroACTA 10mg
A peptide agonist of MC4R; increases cAMP production in CHO-K1 cells expressing MC4R, MC1R, MC3R, and MC5R (EC50s = 0.27, 5.8, 5.3, and 1,600 nM, respectively, for the human receptors) but not in cells expressing MC2R (EC50 = >10 µM); inhibits food intake in MC3R, but not MC4R, knockout mice at 6.4 µmol/animal; reduces food intake and hepatosteatosis, induces weight loss, and decreases serum insulin, glucose, and leptin levels in a mouse model of diet-induced obesity at 300 nmol/kg per day
Cayman Chemical McaSEVNLDAEFRK DnpRRNH2 10mg
A fluorogenic substrate for BACE; Mca is released upon cleavage by BACE and its fluorescence can be used to quantify BACE activity; ex/em = 328/420 nm, respectively
Cayman Chemical Gap 27trIfluoROCTAte salt 10mg
A connexin-mimetic peptide; reduces survival of isolated rat osteoclasts at 500 µM; decreases bone resorption in rat bone slice and osteoclast co-cultures; accelerates wound closure and stratification of the corneal epithelium in isolated human corneas; reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of AV-shunt surgery-induced high-output heart failure
Cayman Chemical LAPtrIfluoroacetate salt 10mg
An antiviral peptide; inhibits the HCV 5’-UTR-PTB and HCV 5’-UTR-PCBP2 interaction; inhibits HCV IRES-mediated translation in a reporter assay using Huh7 cells at 60 µM
Cayman Chemical MCC950sodIum salt 10mg
An inhibitor of NLRP3 inflammasome activation; inhibits ATP-induced IL-1β release in LPS-primed mouse BMDMs (IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1β release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 µM; selective for NLRP3 over NLRC4 and AIM2 inflammasomes and does not inhibit LPS-induced NLRP3 priming in mouse BMDMs at 10 µM; reduces ox-LDL-induced increases in caspase-1 activity and inhibits pyroptosis in THP-1 macrophages at 1 µM; reduces myocardial fibrosis in mice following myocardial infarction induced by left coronary artery ligation at 10 mg/kg; improves forelimb grip strength and reduces spinal edema in a mouse model of spinal crush injury at 10 mg/kg
Cayman Chemical R-Metalaxyl-d6 10mg
An internal standard for the quantification of (R)-(−)-metalaxyl by GC- or LC-MS
Cayman Chemical Xylotetraose 10mg
A xylooligosaccharide; has been found in corn and various plant-based agricultural wastes