Custom Peptides
Cayman Chemical 1 4-PBITdIhydrobromIde 10mg
1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS.{1292} Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
Cayman Chemical Dehydrocostus lacton 10mg
A natural sesquiterpene with anti-cancer and anti-inflammatory actions
Cayman Chemical N6 6AmInohexylcarbamoylme 10mg
An alkylated ADP derivative; has been biotinylated and conjugated to an azidonitrobenzoyl group for use as a photoaffinity probe to visualize the ATPase site of rabbit myosin
Cayman Chemical FlavokawaIn 1I 10mg
A flavokawain derivative with anticancer and antiviral activities; inhibits the proliferation of gefitinib-resistant H1975 NSCLC cells by 36%, as well as decreases protein levels of EGFR, c-Met, HER2, Akt, and Cdk4 and increases protein levels of Hsp70, markers of Hsp90 inhibition, at 30 µM; intramuscular administration reduces viral titers in PRRSV-infected pigs
Cayman Chemical SumatrIptnsuccInate 10mg
An agonist of 5-HT1B and 5-HT1D receptors (IC50s = 9.3 and 7.3 nM, respectively); binds to the 5-HT1F receptor (IC50 = 17.8 nM); induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM); reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of nitroglycerin-induced pain
Cayman Chemical 6-SIalylactosesodIum salt 10mg
A major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus; used to differentiate and characterize the binding domains of viruses that recognize N-acetylneuraminic acid-capped cell surface receptors; also used as an analytical reference standard for quantification in samples such as milk or colostrum
Cayman Chemical 4hydroxy DIPThydroCLOrID 10mg
An analytical reference standard categorized as a tryptamine; induces the HTR in mice; substitutes for DOM in a two-lever drug discrimination test in rats; intended for research and forensic applications
Cayman Chemical UmIfenovIrhydrochlorIde 10mg
A broad-spectrum antiviral agent; inhibits the replication of H5N1 influenza (IC50 = 30 UG/ml) and SARS-CoV-2 in vitro (IC50 = 3.537 µM); inhibits entry of HCV pseudoparticles in Huh7 cells (IC50 = 6 UG/ml); reduces the formation of influenza-induced lung lesions in ferrets at 45 mg/kg
Cayman Chemical ErythrodIol 10mg
A triterpene with diverse biological activities; induces relaxation of isolated rat aortic rings precontracted with phenylephrine (EC50 = 3.38 µM); inhibits the growth of HT-29 adenocarcinoma cells (EC50 = 48.8 µM); induces production of ROS and apoptosis in MCF-7 cells at 100 µM; topical administration reduces TPA-induced EAr edema and MPO activity in mice at 0.5 mg/ear
Cayman Chemical NhexadecnoylLHomoserIn l 10mg
One of a number of lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum-sensing signaling in Sinorhizobium meliloti, a nitrogen-fixing bacterial symbiont of certain legumes; the most abundant AHL produced by the proteobacterium Rhodobacter capsulatus; activates genetic exchange between R. capsulatus cells
Cayman Chemical Obatoclaxmesylate 10mg
An antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd ~500 nM); prevents interaction of these pro-survival proteins with Bax or Bak, inducing apoptosis; also induces autophagy in mouse embryo fibroblasts and in HeLa cell
Cayman Chemical 1 3DIpalmItoleoyl GlycRol 10mg
A diacylglycerol with palmitoleic acid at the sn-1 and sn-3 positions; selectively inhibits α-glucosidase from S. cerevisiae over rat enzyme (IC50s = 4.45 and 9,326.5 μM, respectively); has been used in the formation of lipid bilayers to study the effects of membrane composition and valinomycin on membrane potential
Cayman Chemical SolIthromycIn 10mg
A macrolide antibiotic; active against Gram-positive and Gram-negative bacteria, including C. trachomatis and C. pneumoniae (MICs = 0.125-0.5 and 0.25-1 μg/ml, respectively); inhibits growth of multidrug resistant P. falciparum in vitro (IC50s = 0.5 nM for both Dd2 and 7G8 strains); eradicates P. berghei infection in mice when administered in a four-dose series at 100 mg/kg
Cayman Chemical NnonoylLHomoserIn lacto 10mg
A bacterial quorum-sensing signaling molecule; induces GFP production in E. coli expressing the V. fischeri LuxR-PluxI quorum-sensing operon from 100-1,000 nM